Mauricio Pellegrino has no injury concerns for his team's Premier League trip to Manchester City, with long-term absentee Matt Targett the only player set to skip Wednesday's encounter.
The Argentine has practically a full squad to choose from at the Etihad Stadium, with Mario Lemina having made his first appearance in just over month from the substitute's bench against Everton on Sunday.
Lemina completed the final 12 minutes of Southampton's comprehensive 4-1 victory over the Toffees, his first sight of action since the home meeting with West Bromwich Albion on 21 October.
Saints' midfield options are set to be boosted further by the return of Oriol Romeu after a one-match suspension.