Southampton will travel to face West Bromwich Albion in the fifth round of the Emirates FA Cup.
Mauricio Pellegrino's men will travel to The Hawthorns, with ties to be played between the 16th and 19th February.
Saints met West Brom at St Mary's earlier this season in the Premier League, when Sofiane Boufal's stunning solo effort earned all three points.
The last time the two sides met in the FA Cup was back in 1979, also in the fifth round, when a 1-1 draw at West Brom forced a replay which Saints went on to win 2-1 courtesy of goals from Phil Boyer and David Peach.
A date and ticketing details for next month's game will be confirmed in due course.